Windows 10 Enterprise LTSC 2021 builds on Windows 10 Pro, version 21H2 (released November 2021) adding premium features designed to address the needs of large and mid-size organizations (including large academic institutions), such as advanced protection against modern security threats, full flexibility of OS deployment, updating and support options; as well as comprehensive device and app management and control capabilities.

The LTSC edition provides customers with access to the Long-Term Servicing Channel as a deployment option for their special-purpose devices and environments. This edition will not be updated with any new features, and features from Windows 10 that could be updated with new functionality are not included (e.g., Cortana and all in-box Universal Windows apps). Windows 10 Enterprise N LTSC 2021 includes the same functionality as Windows 10 Enterprise LTSC 2021, except that it does not include certain media related technologies (Windows Media Player, Camera, Music, TV and Movies) or the Skype app.